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Bret H. Goodpaster, PhD

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Bret Goodpaster, Ph.D. is the Director of the Exercise Metabolism Core and Senior Investigator at the TRI and Professor at the Sanford Burnham Medical Research Institute at Lake Nona. Dr. Goodpaster studies the role of exercise on energy metabolism in aging, obesity and diabetes. In his role at the TRI, he will help decipher biological mechanisms underlying the health benefits of exercise that can be translated back into new and better treatments for these conditions.  

Dr. Goodpaster’s primary research is in the pathophysiology of human obesity, insulin resistance, and diabetes. He has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008, awarded to the most outstanding investigator in the US in the field of Aging. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in Type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others?  And which are the good fats and which are the bad fats? 

Dr. Goodpaster has published over 200 peer-reviewed papers, review articles and book chapters, has served on Editorial Boards for Diabetes, the American Journal of Physiology, the Journals of Gerontology, and is currently an Associate Editor for Obesity. He has also served on several NIH grant review panels as well as the American Diabetes Association. 

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University in 1995. Prior to coming to the Florida Hospital TRI, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.