Research Study

Past Study: BNP-3

Study Status: CLOSED

Study Name:   BNP 3

Study Focus:   Metabolism and Obesity



Study Contact: To learn more, please call 1-877-854-8475 or fill out the Contact us form.

Study Purpose:  To evaluate the safety and tolerability of Nesiritide (study drug) or placebo administered by continuous IV infusion for 48 hours in healthy obese subjects.  

To be enrolled in this study, you must meet certain requirements.  You may eligible to participate if you meet the following criteria:

  • Healthy obese nondiabetic, men and women
  • Ages 40 – 65 years
  • BMI greater than or equal to 30 kg/m2

Study Duration: up to 9 weeks consisting of 5 total visits

Study Commitment:

  • Visit 1 – Screening Visit
  • Visit 2 – 4-day, 3-night inpatient stay  
  • Visit 3 – Follow-up biopsy check
  • Visit 4 – 4-day, 3-night inpatient stay
  • Visit 5 – Follow-up biopsy check

Study Procedures:

  • Medical and medication history
  • Physical Exam, vital signs, height, weight, EKG
  • Dual Energy X-ray Absorptiometry (DEXA) to measure body composition
  • IV insertion for study drug or placebo infusion and blood draws
  • Resting Metabolic Rate (RMR) Measurement
  • Muscle Tissue and Adipose (Fat) Biopsies

Compensation offered? Yes $1,250.00

This study is being conducted under the direction of Dr. Pratley, at 301 East Princeton Street, Orlando, Florida 32804.